Reaktion #93458

Reaktionsgleichung

ethyl glyoxylate

benzyl carbamate

water

→

ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate

Ausbeute 64.9%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting reaction mixture
2. 2
   Einengenwas concentrated in vacuo, and diethyl ether
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   FiltrationThe mixture was filtered
5. 5
   Sonstigethe diethyl ether solution was evaporated in vacuo

Vorschrift

A solution of 17.3 g (0.169 mole) of ethyl glyoxylate and 23.0 g (0.152 mole) of benzyl carbamate in 250 ml of toluene was heated under reflux for 6 hours, with removal of water using a Dean-Stark trap. The resulting reaction mixture was concentrated in vacuo, and diethyl ether was added to the residue. The mixture was filtered, and the diethyl ether solution was evaporated in vacuo to give 25.0 g of ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate as a sticky solid.

Quelle