Reaktion #93424

Reaktionsgleichung

ethyl acetate

ethyl veratroylacetate

N-methylurea

→

6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione

Ausbeute 40.3%

Lösungsmittel

tetralin

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter being cooled to 95° C.
2. 2
   FiltrationThe precipitate was collected by filtration
3. 3
   Waschenwashed with ethyl acetate

Vorschrift

To a solution of ethyl veratroylacetate (8.0 g) in tetralin (24 ml) was added N-methylurea (3.52 g) and the mixture was heated for an hour at 170° C. After being cooled to 95° C., ethyl acetate (33 ml) was added thereto. The precipitate was collected by filtration and washed with ethyl acetate to give 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione (3.35 g).

Quelle