Reaktion #933873

Reaktionsgleichung

1,5-dioxa-8-azaspiro[5.4]decane benzyl carbamate

hydrogen

→

title compound

1,5-dioxa-8-azaspiro[5.4]decane

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe protecting group was removed
2. 2
   SonstigeThe catalyst was removed by filtration
3. 3
   Sonstigethe solvent was removed under vacuum

Vorschrift

The protecting group was removed by dissolving 2.09 g (7.5 mmol) of 1,5-dioxa-8-azaspiro[5.4]decane benzyl carbamate, from Step 1, in 100 mL of methanol, adding 0.50 g of 20% Pd/C, and hydrogenating at room temperature under 4 atm of hydrogen for 24 hours. The catalyst was removed by filtration, then the solvent was removed under vacuum to afford the title compound, MS: M/Z 144 (M+H), which was taken directly to the next step.

Quelle