Reaktion #933233

Reaktionsgleichung

2-chloro-6-trifluoromethyl pyridine

piperazine

→

1-[6-(trifluoromethyl)-2-pyridinyl]piperazine

Ausbeute 81.4%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture is filtered
2. 2
   Waschenwashed with acetonitrile
3. 3
   SonstigeThe solvent is evaporated
4. 4
   Waschenwashed with water
5. 5
   TrocknenThe solution is dried over magnesium sulfate
6. 6
   SonstigeThe solvent is evaporated
7. 7
   workup.DISTILLATIONthe residue distilled

Vorschrift

54.4 g of 2-chloro-6-trifluoromethyl pyridine are dissolved into a mixture of 350 ml of acetonitrile and 77.4 g of anhydrous piperazine. The mixture is filtered and washed with acetonitrile. The solvent is evaporated. The residue is taken up with dichloromethane and washed with water. The solution is dried over magnesium sulfate. The solvent is evaporated and the residue distilled, to obtain 56.4 g of 1-[6-(trifluoromethyl)-2-pyridinyl]piperazine (81.4% yield), having a boiling point of 103° C. at 0.05 mm Hg.

Quelle