Reaktion #93310

Reaktionsgleichung

ethoxycarbonylacetylchloride

2-amino-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole

sodium hydrogen chloride

→

2-ethoxycarbonylacetylamino-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole

Ausbeute 61.0%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTo the solution was added under ice-
2. 2
   ExtraktionThe resultant was subjected to extraction with ethyl acetate
3. 3
   WaschenThe organic layer was washed with water
4. 4
   Sonstigedried
5. 5
   Einengenconcentrated
6. 6
   Sonstigefollowed by recrystallization from tetrahydrofuran

Vorschrift

In 5 ml of dimethylformamide was dissolved 1 g of 2-amino-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole. To the solution was added under ice-cooling 580 mg of ethoxycarbonylacetylchloride. The mixture was stirred for 30 minutes, to which was then added a saturated aqueous solution of sodium hydrogen chloride. The resultant was subjected to extraction with ethyl acetate. The organic layer was washed with water, dried and concentrated, followed by recrystallization from tetrahydrofuran to give 850 mg (61%) of 2-ethoxycarbonylacetylamino-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole, m.p. 202°-203° C.

Quelle