Reaktion #933004

Reaktionsgleichung

oxymorphone

O-methyl hydroxylamine hydrochloride

NaOH

MeOH

→

6-Methyloximino-17-methyl-4,5α-epoxy-3,14-dihydroxymorphinan

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   Extraktionextracted with 150 mL CHCl3 (3×50 mL)
3. 3
   TrocknenThe combined extracts were dried (MgSO4)
4. 4
   Sonstigeevaporated
5. 5
   SonstigeThe residue obtained
6. 6
   Sonstigewas recrystallized from CH2Cl2 -hexane
7. 7
   Sonstigeto yield 0.84 g on the product
8. 8
   SonstigeIt was further purified by flash column chromatography on silica gel
9. 9
   Wascheneluting with EtOAc-EtOH-NH4OH (100:1:1) (approx. size 40 microns)
10. 10
    SonstigeThe combined fractions were evaporated in vacuo
11. 11
    Sonstigethe residue obtained
12. 12
    Sonstigewas recrystallized from hexane-petroleum ether
13. 13
    SonstigeIR: (KBr): No C=O absorption at 1730 cm-1

Vorschrift

A solution of oxymorphone (0.9 g, 3 mmol) and O-methyl hydroxylamine hydrochloride (0.33 g, 3.9 mmol) in 15 mL MeOH containing 1.6 mL of 10% aqueous NaOH was refluxed for 5 h, cooled, diluted with water (approximately 100 mL) and extracted with 150 mL CHCl3 (3×50 mL). The combined extracts were dried (MgSO4), and evaporated. The residue obtained was recrystallized from CH2Cl2 -hexane to yield 0.84 g on the product. It was further purified by flash column chromatography on silica gel, eluting with EtOAc-EtOH-NH4OH (100:1:1) (approx. size 40 microns). The combined fractions were evaporated in vacuo and the residue obtained was recrystallized from hexane-petroleum ether. Yield: 0.4 g (40%). mp 115°-116° C. IR: (KBr): No C=O absorption at 1730 cm-1. H NMR (CDCl3)δ4.92 (s,C5H), 3.85 (s, OCH3) Rf: silica gel 60 in EtOAc-EtOH-NH4OH (100:1:1) 0.30. Anal. Calcd for: C18H22N2O4 : C, 65.44; H, 6.71; N, 8.48. Found: C, 65.51; H, 6.74; N, 8.46.

Quelle