Reaktion #93241

ord-b694f4419f0c49708dc08209ccec080e

Reaktionsgleichung

O
Water
CC(C)(C)[O-].[K+]
Potassium tert-butoxide
CC(=O)N1c2ccccc2Sc2cc(O)c3ccccc3c21
12-acetyl-5-hydroxy-12H-benzo[a]phenothiazine
CI
methyl iodide
→
COc1cc2c(c3ccccc13)N(C(C)=O)c1ccccc1S2
title compound
COc1cc2c(c3ccccc13)N(C(C)=O)c1ccccc1S2
12-Acetyl-5-methoxy-12H-benzo[a]phenothiazine

Edukte

O
Water
CC(C)(C)[O-].[K+]
Potassium tert-butoxide
CC(=O)N1c2ccccc2Sc2cc(O)c3ccccc3c21
12-acetyl-5-hydroxy-12H-benzo[a]phenothiazine
CI
methyl iodide

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Filtrationthe precipitate was filtered

Vorschrift

Potassium tert-butoxide (800 mg) was added to a solution of 12-acetyl-5-hydroxy-12H-benzo[a]phenothiazine (950 mg) (from Example 3) and methyl iodide (1.5 ml) in DMF (10 ml) and stirred for 15 minutes. Water (80 ml) was added to the reaction mixture and the precipitate was filtered to afford the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04611056uspto-grants-1986_09