Reaktion #931431

Reaktionsgleichung

1-(2-(N-allylamino)ethyl)-6-(3-thienyl)-1H-indazole

→

title product

Ausbeute 81.0%

1-(2-(N-propylamino)ethyl)-6-(3-thienyl)-1H-indazole

Ausbeute 81.0%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationFiltration through an SPE cartridge (Supelco, 6 mL, silica gel, 1000 mg, gradient from 0-10% 2M methanolic ammonia in ethyl acetate)

Vorschrift

A small scoop of palladium on carbon (10%˜10 mg, catalytic) was added to a solution of 1-(2-(N-allylamino)ethyl)-6-(3-thienyl)-1H-indazole (15 mg, 0.053 mmol) in ethyl acetate (1 mL). The resulting mixture was stirred under an atmosphere of hydrogen gas in a balloon for 1 h. Filtration through an SPE cartridge (Supelco, 6 mL, silica gel, 1000 mg, gradient from 0-10% 2M methanolic ammonia in ethyl acetate) gave the title product (12.2 mg, 81%).

Quelle