Reaktion #931202

Reaktionsgleichung

1,4-Dioxa-spiro[4.5]decane-8-carbonitrile

hydrochloric acid

→

oil

Ausbeute 50.8%

4-Oxo-cyclohexanecarbonitrile

Ausbeute 50.8%

Lösungsmittel

ethyl acetate

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water and brine
2. 2
   Trocknendried over MgSO4
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated to an oil which
5. 5
   Sonstigewas purified via flash chromatography on silica using 10% ethyl acetate/hexane as eluent

Vorschrift

A solution of 1,4-Dioxa-spiro[4.5]decane-8-carbonitrile (2.0 grams, 12.8 mmole) and 2 N hydrochloric acid (21.0 grams, 42.0 mmole) in tetrahydrofuran (30 ml) at room temperature was stirred over night. The mixture was diluted with ethyl acetate, washed with water and brine, dried over MgSO4, filtered, and concentrated to an oil which was purified via flash chromatography on silica using 10% ethyl acetate/hexane as eluent to give an oil (0.800 g). MW 123.15.

Quelle