Reaktion #930750

Reaktionsgleichung

glycerol

1-O-benzyl-3-O-t-butyldimethylsilyl-2-O-methyl-rac-glycerol

→

1-O-t-butyldimethylsilyl-2-O-methyl-rac-glycerol

Ausbeute 99.0%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas evacuated
2. 2
   workup.ADDITIONfilled with hydrogen
3. 3
   Sonstigethe reaction
4. 4
   Filtrationthe mixture was filtered through Celite
5. 5
   Sonstigethe filtrate was evaporated to dryness

Vorschrift

A mixture of the protected glycerol derivative 14 (5.0 g, 16 mmol) and 10% palladium on activated carbon (wet Degussa type E101 NE/W) (0.43 g) in MeOH (50 mL) was evacuated using an aspirator pump and filled with hydrogen. After 2 h, TLC analysis showed the reaction to be complete, the mixture was filtered through Celite and the filtrate was evaporated to dryness to give 1-O-t-butyldimethylsilyl-2-O-methyl-rac-glycerol (15) (99%) as a colourless oil.

Quelle