Reaktion #92972

Reaktionsgleichung

1,4-dichloro-2-butanol

m-trifluoromethylphenol

potassium hydroxide

→

4-Chloro-1-(3-trifluoromethylphenoxy)-2-butanol

Lösungsmittel

water

water

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting reaction mixture
2. 2
   Extraktionextracted with 400 ml
3. 3
   ExtraktionThe ether extract
4. 4
   Waschenwas washed with 0.5N sodium hydroxide
5. 5
   Trocknenwith water, dried over sodium sulfate
6. 6
   workup.DISTILLATIONdistilled under reduced pressure
7. 7
   workup.DISTILLATIONThe distillate which was collected at 120°-124° C./0.01 mm
8. 8
   Sonstigesolidified at room temperature

Vorschrift

To a mixture of 0.5 mole (75 g.) of m-trifluoromethylphenol, 1 mole (56 g.) of potassium hydroxide, 100 ml. of water and 400 ml. of isopropanol was added 0.6 mole (84 g.) of 1,4-dichloro-2-butanol with stirring at temperature below 55° C. The resulting reaction mixture was heated at 65° C. for 20 hr., mixed with 2 liters of water, and extracted with 400 ml. of isopropyl ether. The ether extract was washed with 0.5N sodium hydroxide and then with water, dried over sodium sulfate and distilled under reduced pressure. The distillate which was collected at 120°-124° C./0.01 mm. solidified at room temperature and melted at 50°-52° C.

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