Reaktion #92849

Reaktionsgleichung

product

Ethyl 5-aminocarbonyl-4,6-diethoxy-2-(trifluoromethyl)-3-pyridinecarboxylate

→

product

Ausbeute 24.6%

Ethyl 5-cyano-4,6-diethoxy-2-(trifluoromethyl)-3-pyridinecarboxylate

Ausbeute 24.6%

Lösungsmittel

POCl3

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 7 hours
2. 2
   Einengenconcentrated in vacuo
3. 3
   workup.ADDITIONThe residue was poured into water
4. 4
   Extraktionextracted with ether
5. 5
   ExtraktionThe ether extract
6. 6
   Waschenwas washed with 15% K2CO3
7. 7
   Trocknendried (MgSO4)
8. 8
   Einengenconcentrated

Vorschrift

A mixture of 6.17 g (0.018 mol) of product of Example 23 and 100 ml of POCl3 was held at reflux for 7 hours and concentrated in vacuo. The residue was poured into water and extracted with ether. The ether extract was washed with 15% K2CO3, dried (MgSO4) and concentrated to give 1.44 g (24.6%) of product as an oil; nD25 1.4677.

Quelle