Reaktion #92844

Reaktionsgleichung

dimethyl acetonedicarboxylate

sodium acetate

HCl

trifluoroacetonitrile

→

product

Ausbeute 25.0%

Methyl 4,6-dihydroxy-2(trifluoromethyl)-3-pyridinecarboxylate

Ausbeute 25.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigein 4 hours
2. 2
   TemperaturThe reaction mixture was cooled
3. 3
   SonstigeThe insoluble material was collected

Vorschrift

To a well stirred mixture of 84.35 g (0.484 mol) of dimethyl acetonedicarboxylate, 200 ml of saturated sodium acetate, and 400 ml of ethanol at 70° C. was passed 49 g of trifluoroacetonitrile in 4 hours. The reaction mixture was cooled and poured into a mixture of 100 ml of concentrated HCl and 1000 g of ice. The insoluble material was collected to give 28.7 g (25%) of product: mp 235°-238.5° C. (dec).

Quelle