Reaktion #92815

Reaktionsgleichung

triphenylphosphine

(2,4-difluorophenyl) boronic acid

potassium carbonate

2,5-dibromopyridine

→

5-bromo-2-(2,4-difluorophenyl)pyridine

Ausbeute 84.0%

Lösungsmittel

water

acetonitrile

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate

Vorschrift

One 1.0 L round bottom flask was charged with 2,5-dibromopyridine (10.45 g, 44.1 mmol); (2,4-difluorophenyl) boronic acid (7.66 g, 48.5 mmol); potassium carbonate (12.19 g, 88 mmole); diacetoxypalladium (0.495 g, 2.206 mmol); triphenylphosphine (1.157 g, 4.41 mmol); and acetonitrile (348 ml) and MeOH (174 ml). The reaction mixture was heated to 40° C. for 40 hours. The reaction mixture was diluted with deionized water and extracted with ethyl acetate. The organic portion was combined and subjected to column chromatography (SiO2 gel, 10% EtOAc in heptane) to yield the desired compound, 5-bromo-2-(2,4-difluorophenyl)pyridine (10 g; 84%).

Quelle