Reaktion #92811

ord-d2361c97e90743c2bd9752cc01be3734

Reaktionsgleichung

N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O
Nε-benzyloxycarbonyl-L-lysine
N[C@@H](CC(Cc1ccccc1)C(=O)O)C(=O)O
γ-benzyl-L-glutamic acid
N[C@@H](CC(Cc1ccccc1)C(=O)O)C(=O)O
γ-benzyl-L-glutamic acid
N[C@@H](CC(Cc1ccccc1)C(=O)O)C(=O)O
γ-benzyl-L-glutamic acid
N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O
Nε-benzyloxycarbonyl-L-lysine
N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O
Nε-benzyloxycarbonyl-L-lysine
N[C@@H](CC(Cc1ccccc1)C(=O)O)C(=O)O.N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O
γ-benzyl-L-glutamic acid Nε-benzyloxycarbonyl-L-lysine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The synthesized copolymer (10 mg) was dissolved in deuterated trifluoroacetic acid, and the 1H NMR was measured. As a result, a peak derived from the benzyl group of Nε-benzyloxycarbonyl-L-lysine and the benzyl group of γ-benzyl-L-glutamic acid was detected near 5.1 ppm, a peak derived from the proton at the α-position of γ-benzyl-L-glutamic acid was detected near 4.7 ppm, and a peak derived from the proton at the α-position of Nε-benzyloxycarbonyl-L-lysine was detected near 4.4 ppm. When the peak areas near 5.1 ppm, 4.7 ppm, 4.4 ppm are A, B, C, respectively, A/B=4.00, A/C=4.00, and B/C=1.00. Since both B and C represent an area of one proton, the composition of the copolymer is γ-benzyl-L-glutamic acid (50%)/Nε-benzyloxycarbonyl-L-lysine (50%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09450174B2uspto-grants-2016_09