Reaktion #92734

Reaktionsgleichung

methyl 3-[(2S)-2-{[(1S)-1-phenylethyl]amino}propyl]benzoate

ammonium formate

→

methyl 3-[(2S)-2-aminopropyl]benzoate

Ausbeute 98.9%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered over Celite
2. 2
   Sonstigethe solvent was then evaporated under reduced pressure
3. 3
   workup.ADDITIONTo the obtained residue were added a saturated aqueous sodium hydrogen carbonate solution and chloroform
4. 4
   Sonstigea layer separation operation
5. 5
   Trocknenby drying over anhydrous magnesium sulfate
6. 6
   SonstigeThe solvent was evaporated under reduced pressure

Vorschrift

To a solution of 280 mg of methyl 3-[(2S)-2-{[(1S)-1-phenylethyl]amino}propyl]benzoate in 6.8 ml of ethanol were added 30 mg of 20% palladium-carbon hydroxide (wet) and 320 mg of ammonium formate, followed by stirring at 80° C. for 4 hours. The reaction mixture was filtered over Celite and the solvent was then evaporated under reduced pressure. To the obtained residue were added a saturated aqueous sodium hydrogen carbonate solution and chloroform to carry out a layer separation operation, followed by drying over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain 180 mg of methyl 3-[(2S)-2-aminopropyl]benzoate.

Quelle