Reaktion #92726

Reaktionsgleichung

methyl 3-formylbenzoate

(R)-2-methyl-2-propanesulfinamide

→

methyl 3-[(E)-{[(R)-tert-butylsulfinyl]imino}methyl]benzoate

Ausbeute 14.3%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered over Celite
2. 2
   Sonstigethe solvent was then evaporated under reduced pressure
3. 3
   SonstigeThe obtained residue was purified by silica gel column chromatography

Vorschrift

A suspension of 3.0 g of methyl 3-formylbenzoate, 2.25 g of (R)-2-methyl-2-propanesulfinamide, and 6.0 g of copper (II) sulfate in 50 ml of dichloromethane was stirred overnight. The reaction mixture was filtered over Celite and the solvent was then evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 700 mg of methyl 3-[(E)-{[(R)-tert-butylsulfinyl]imino}methyl]benzoate.

Quelle