Reaktion #927238

Reaktionsgleichung

Propargylamine

methyl trifluoroacetate

→

N-propargyltrifluoroacetamide

Ausbeute 86.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto react at 0° C. for two hours

Vorschrift

Propargylamine (Aldrich, 25 g, 0.45 mol) was added dropwise to methyl trifluoroacetate (Tokyo Chemical Industry Co., Ltd., 69.2 g, 0.54 mol) cooled to 0° C. They were allowed to react at 0° C. for two hours to afford 43.8 g (86.0%) of N-propargyltrifluoroacetamide after purification by vacuum distillation (23 mmHg, boiling point; 77° C.).

Quelle