Reaktion #92687

Reaktionsgleichung

sodium hydrogen carbonate

bromoacetone

methyl 6-amino-5-[(2-fluorobenzyl)oxy]nicotinate

bromoacetone

→

methyl 8-[(2-fluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-6-carboxylate

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGby stirring at 80° C. for 4 hours
2. 2
   Sonstigethe solvent was evaporated under reduced pressure
3. 3
   Extraktionby extracting with ethyl acetate
4. 4
   Waschenwashing with saturated brine
5. 5
   TrocknenAfter drying over anhydrous magnesium sulfate
6. 6
   Filtrationfiltering
7. 7
   Sonstigethe solvent was evaporated under reduced pressure
8. 8
   SonstigeThe obtained residue was purified by silica gel column chromatography

Vorschrift

To a suspension of 2.15 g of methyl 6-amino-5-[(2-fluorobenzyl)oxy]nicotinate in 43 ml of ethanol was added 1.09 ml of bromoacetone, followed by stirring at 80° C. for 4 hours. To the reaction mixture was added 1.09 ml of bromoacetone, followed by stirring at 80° C. for 4 hours. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution, and the solvent was evaporated under reduced pressure, followed by extracting with ethyl acetate and washing with saturated brine. After drying over anhydrous magnesium sulfate and then filtering, the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 1.39 g of methyl 8-[(2-fluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-6-carboxylate.

Quelle