Reaktion #926868

Reaktionsgleichung

hydrochloric acid

2-cyclopentyl-2-phenyl-5-hydroxy-6,7-dichloro-1-indanone

potassium carbonate

ethyl bromoacetate

sodium hydroxide

→

(1-Oxo-2-cyclopentyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetic acid

Lösungsmittel

water

dimethylformamide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis warmed at 55°-60° C. for 3 hours
2. 2
   Sonstigeto precipitate 680 mg
3. 3
   Sonstigeof (1-oxo-2-cyclopentyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 184°-186° C. after crystallization from nitromethane

Vorschrift

A stirred mixture of 2-cyclopentyl-2-phenyl-5-hydroxy-6,7-dichloro-1-indanone (1.10 g., 0.003 mole), potassium carbonate (0.85 g., 0.006 mole) and ethyl bromoacetate (1.02 g., 0.006 mole) in dimethylformamide (20 ml.) is warmed at 55°-60° C. for 3 hours, then treated with water (20 ml.)-10N sodium hydroxide solution (1.2 ml., 0.012 mole) and heated at 100° C. for one hour. The reaction mixture is added slowly to water (300 ml.)-12N hydrochloric acid (5 ml.) to precipitate 680 mg. of (1-oxo-2-cyclopentyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 184°-186° C. after crystallization from nitromethane.

Quelle