Reaktion #92675

Reaktionsgleichung

5-methyl-2-nitropyridin-3-ol

(bromomethyl)cyclohexane

potassium carbonate

water

→

3-(cyclohexylmethoxy)-5-methyl-2-nitropyridine

Lösungsmittel

DMF

hexane ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter leaving
2. 2
   Temperaturto be cooled at room temperature, to the reaction mixture
3. 3
   Sonstigea layer separation operation
4. 4
   WaschenThe organic layer was washed with water and saturated brine
5. 5
   Trocknendried over anhydrous magnesium sulfate
6. 6
   Sonstigethe solvent was evaporated under reduced pressure

Vorschrift

A suspension of 1 g of 5-methyl-2-nitropyridin-3-ol, 1.35 ml of (bromomethyl)cyclohexane, and 1.79 g of potassium carbonate in 10 ml of DMF was stirred at 78° C. for 12 hours. After leaving to be cooled at room temperature, to the reaction mixture were added water and hexane/ethyl acetate to carry out a layer separation operation. The organic layer was washed with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain 1.8 g of 3-(cyclohexylmethoxy)-5-methyl-2-nitropyridine.

Quelle