Reaktion #9267

Reaktionsgleichung

6-bromo-1,3-benzothiazol-2-amine

ethylisocyanate

triethylamine

→

N-(6-Bromo-1,3-benzothiazol-2-yl)-N′-ethylurea

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthen cooled to RT
2. 2
   SonstigeThe solvent is removed in vacuo
3. 3
   Waschenthe solids are washed well with ether
4. 4
   SonstigeThe product is further purified by column chromatography

Vorschrift

About 0.75 g of 6-bromo-1,3-benzothiazol-2-amine (crude) is dissolved in about 15 mL DMF. About 0.5 mL of ethylisocyanate is added followed by about 0.9 mL triethylamine and the solution is heated to about 80° C. under good agitation. The solution is allowed to stir for about 4 hours then cooled to RT. The solvent is removed in vacuo and the solids are washed well with ether. The product is further purified by column chromatography.

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