Reaktion #926102

Reaktionsgleichung

3-[N'-formyl-N'-(3-hydroxypropyl)amino]-1-propanamine hydrochloride

3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride

hydrochloride

3-[N-(3-chloropropyl)methylamino]-N,N,N-trimethyl-propan-1-aminium chloride

thionyl chloride

3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride

iodomethane

hydrochloric acid

N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide

oxetane

sodium carbonate

→

3-[N'-formyl-N'-(3-hydroxypropyl)amino]N,N,N-trimethyl-propan-1-aminium chloride

Reaktionsbedingungen

Vorschrift

The hydrochloride of 3-[N-(3-chloropropyl)methylamino]-N,N,N-trimethyl-propan-1-aminium chloride has been prepared by reacting thionyl chloride with 3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride. This 3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride has been prepared (a) by heating N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide with oxetane, and treating the resulting product with concentrated hydrochloric acid; and (b) by reacting 3-[N'-formyl-N'-(3-hydroxypropyl)amino]-1-propanamine hydrochloride with iodomethane in the presence of sodium carbonate to form 3-[N'-formyl-N'-(3-hydroxypropyl)amino]N,N,N-trimethyl-propan-1-aminium chloride, and reacting the latter with formalin in formic acid followed by concentrated hydrochloric acid.

Quelle