Reaktion #9253

Reaktionsgleichung

N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N′-ethylurea

DDQ

→

N-Ethyl-N′-(8H-[1,3]thiazolo[4,5-g]indol-2-yl)urea

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe crude material was purified by preparative HPLC
2. 2
   Sonstige3 mg (4%, 2 steps) pure product was isolated
3. 3
   SonstigeRP-BPLC RT 10.45 min.

Vorschrift

To a suspension of N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N′-ethylurea (81 mg, 0.308 mmol) in toluene (3.5 mL) was added DDQ (78 mg, 0.34 mmol). The reaction mixture was stirred at about 45° C. for about 4 hrs. The reaction mixture was pumped down and the crude material was purified by preparative HPLC. 3 mg (4%, 2 steps) pure product was isolated. LC/MS 262 (MH+); RP-BPLC RT 10.45 min.

Quelle