Reaktion #9251

Reaktionsgleichung

N-ethyl-N′-(7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)urea

formaldehyde

methylamine

N-methylmorpholine

→

pure product

Ausbeute 100.9%

2-(3-Ethyl-5-methyl-2-oxo-1,3,5-triazinan-1-yl)-4,5,6,7-tetrahydro-1,3-benzothiazol-7-one

Ausbeute 100.9%

Lösungsmittel

EtOH H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigea solution had been formed

Vorschrift

To a suspension of N-ethyl-N′-(7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)urea (10.0 g, 41.79 mmol) in EtOH/H2O (1/1, 300 mL) were added formaldehyde (37 wt % in H2O, 20.4 g, 417.87 mmol), methylamine (40 wt % in H2O, 10.8 mL, 125.37 mmol) and N-methylmorpholine (11.8 mL, 83.6 mmol). The suspension was heated to about 60° C. for about 5 hrs, then a solution had been formed. The reaction mixture was pumped down in vacuo to give 12.41 g (quantitative yield) pure product.

Quelle