Reaktion #92484

Reaktionsgleichung

2-amino-6-methoxybenzoic acid

acrolein

→

title compound

Ausbeute 20.9%

7-methoxyquinoline-8-carboxylic acid

Ausbeute 20.9%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture was concentrated
2. 2
   Sonstigepurified via silica gel chromatography (0-10% MeOH in DCM)

Vorschrift

In separate batches (1 g) a mixture of 2-amino-6-methoxybenzoic acid (11 g, 66 mmol) and acrolein (4.8 mL, 72 mmol) in 1,4-dioxane (66 mL) was heated in a microwave reactor for 20 min at 200° C. After combining the reactions, the mixture was concentrated and purified via silica gel chromatography (0-10% MeOH in DCM) to give the title compound (2.8 g, 20%). MS (ESI) mass calcd. for C11H19NO3, 203.1. m/z found 204.0 [M+H]+.

Quelle