Reaktion #9248

Reaktionsgleichung

N-ethyl-N′-[7-(3-pyridyl)-4,5-dihydro[1,3]thiazolo[4′,5′: 3,4]benzo[d]-[1,3]thiazol-2-yl]urea

DDQ

→

pure product

Ausbeute 30.1%

N-Ethyl-N′-[7-(3-pyridyl)[1,3]thiazolo[4′,5′: 3,4]benzo[d][1,3]thiazol-2-yl]urea

Ausbeute 30.1%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated in vacuo
2. 2
   Sonstigepurified by preparative HPLC

Vorschrift

A suspension of N-ethyl-N′-[7-(3-pyridyl)-4,5-dihydro[1,3]thiazolo[4′,5′: 3,4]benzo[d]-[1,3]thiazol-2-yl]urea (10 mg, 0.028 mmol) and DDQ (13 mg, 0.056 mmol) in toluene (1 mL) was heated to about 35° C. for about 3 hrs. The reaction mixture was concentrated in vacuo and purified by preparative HPLC. 3 mg (30%) pure product was isolated. LC/MS 356 (MH+); RP-HPLC 14.25 min.

Quelle