Reaktion #92472

Reaktionsgleichung

1-bromo-3-methoxy-5-nitrobenzene

ammonium chloride

→

3-bromo-5-methoxyaniline

Ausbeute 92.0%

Lösungsmittel

THF

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   workup.ADDITIONThe filtrate was diluted with water
3. 3
   Extraktionextracted as in Example 1(d)
4. 4
   workup.DISTILLATIONThe solvent was distilled off
5. 5
   Sonstigeto afford the product in 92% yield (0.8 g)

Vorschrift

To a solution of 1-bromo-3-methoxy-5-nitrobenzene (1 g, 4.33 mmol) in THF (10 ml) were added a solution of ammonium chloride (1.83 g, 34.6 mmol, 8 eq.) in water (5 ml) and zinc (1.93 g, 34.6 mmol, 8 eq.). The mixture was stirred at RT for 30 min and filtered. The filtrate was diluted with water and extracted as in Example 1(d). The solvent was distilled off to afford the product in 92% yield (0.8 g).

Quelle