Reaktion #92418

Reaktionsgleichung

N-(3-(4-bromo-2-nitro-phenylamino)-5-(1H-1,2,4-triazol-1-yl)phenyl)acetamide

calcium chloride

→

N-(3-(2-amino-4-bromophenylamino)-5-(1H-1,2,4-triazol-1-yl)phenyl)acetamide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   workup.ADDITIONThe filtrate was diluted with water
3. 3
   Extraktionextracted as in Example 1(d)
4. 4
   workup.DISTILLATIONThe solvent was distilled off

Vorschrift

To a solution of the compound of Example 155(c) N-(3-(4-bromo-2-nitro-phenylamino)-5-(1H-1,2,4-triazol-1-yl)phenyl)acetamide (5.2 g, 12.5 mmol) in ethanol (100 ml) were added calcium chloride (2.78 g, 25 mmol, 2 eq.) and iron powder (1.3 g, 25 mmol, 2 eq.) and the mixture was heated at 100° C. for 4 h and filtered. The filtrate was diluted with water and extracted as in Example 1(d). The solvent was distilled off and the crude residue was directly used for the next step.

Quelle