Reaktion #924

Reaktionsgleichung

methyl chloroformate

N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-2-sulfonamide

n-butyllithium

→

title compound

Ausbeute 14.3%

Methyl 2-[[(1,1-Dimethylethyl)amino]sulfonyl]-1-methyl-1H-pyrrole-3-carboxylate

Ausbeute 14.3%

Lösungsmittel

THF

ethyl acetate

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe temperature below -58° C
2. 2
   Sonstige1 h
3. 3
   Sonstigeat 0° C.
4. 4
   Sonstigewas recooled to -70° C.
5. 5
   workup.STIRRINGThe reaction mixture was stirred overnight at ambient temperature
6. 6
   WaschenThis solution was washed successively with two 60 mL portions of 1N HCl, brine
7. 7
   Trocknendried (Na2SO4)
8. 8
   Sonstigeevaporated to a dark oil
9. 9
   SonstigeThe crude product was purified by chromatography on silica gel (30% ethyl acetate/70% hexanes)
10. 10
    Sonstigethen collected from hexanes

Vorschrift

To a solution of 2.5 g (11.5 mmol) of N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-2-sulfonamide in 50 mL THF under nitrogen atmosphere cooled to below -70° C. was added dropwise 13 mL (32.5 mmol) of 2.5M n-butyllithium at such a rate as to keep the temperature below -58° C. After stirring at -20° C. to -10° C. for 30 min then 1 h at 0° C., the mixture was recooled to -70° C. and treated with a solution of 1.63 g (17.3 mmol) of methyl chloroformate in 6 mL THF causing an exotherm to -57° C. The reaction mixture was stirred overnight at ambient temperature then diluted with 200 mL of ethyl acetate. This solution was washed successively with two 60 mL portions of 1N HCl, brine, then dried (Na2SO4) and evaporated to a dark oil. The crude product was purified by chromatography on silica gel (30% ethyl acetate/70% hexanes) then collected from hexanes to afford 0.45 g of the title compound, m.p. 105°-108° C.

Quelle