Reaktion #92388

Reaktionsgleichung

N-(3-amino-5-pyrrol-1-yl-phenyl)acetamide

4-bromo-1-fluoro-2-nitrobenzene

potassium fluoride

→

N-(3-(4-bromo-2-nitrophenylamino)-5-(1H-pyrrol-1-yl)phenyl)acetamide

Ausbeute 63.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas brought to RT
2. 2
   SonstigeDMF was removed under vacuum
3. 3
   Sonstigeto get the compound in 63% yield (6.1 g)

Vorschrift

To a solution of N-(3-amino-5-pyrrol-1-yl-phenyl)acetamide (5 g, 23.23 mmol) in anhydrous DMF (5 ml), 4-bromo-1-fluoro-2-nitrobenzene (5.11 g, 23.23 mmol) and potassium fluoride (1.35 g, 23.23 mmol) were added. The mixture was stirred at 110° C. for overnight. Then the mixture was brought to RT and DMF was removed under vacuum. Residue was subjected to flash column chromatography (50% ethyl acetate in hexanes) to get the compound in 63% yield (6.1 g).

Quelle