Reaktion #92369

Reaktionsgleichung

compound

N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2′,4′-difluorobiphenyl-3-yl)acetamide

NaOH

→

5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2′,4′-difluorobiphenyl-3-amine

Ausbeute 58.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was quenched
2. 2
   Extraktionextracted as in Example 1(d)
3. 3
   workup.DISTILLATIONThe solvent was distilled off
4. 4
   Sonstigeto afford the product in 58% yield (0.8 g)

Vorschrift

To a solution of the compound of Example 8 (1.5 g, 3.0 mmol) in ethanol (30 ml) was added aqueous solution of NaOH (1.5 g, 37.5 mmol, 12.5 eq.) and the mixture was heated at 100° C. for 4 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford the product in 58% yield (0.8 g).

Quelle