Reaktion #9236

Reaktionsgleichung

phenyl isocyanate

1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea

triethylamine

→

desired compound

Ausbeute 22.0%

1(6-(3-Phenylaminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea

Ausbeute 22.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGIt was stirred for about 2.5 hours
2. 2
   Sonstigequenched with MeOH
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated
5. 5
   Sonstigepurified by HPLC

Vorschrift

A solution of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea (0.033 g, 0.10 mmol) in 1 mL anhydrous DMF was treated with triethylamine (0.028 mL, 0.20 mmol, 2.0 eq) at room temperature. It was stirred for about 5 min, followed by the addition of phenyl isocyanate (0.013 mL, 0.12 mmol, 1.2 eq). It was stirred for about 2.5 hours, quenched with MeOH, filtered, concentrated, and purified by HPLC to give the desired compound 0.009 g (22%). LC/MS 412.2 (M+1); LC retention time 2.80 min.

Quelle