Reaktion #92356

Reaktionsgleichung

ethyl 2-(pyrrolidin-1-yl)acetate

→

2-(Pyrrolidin-1-yl) acetic acid

Ausbeute 54.0%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was concentrated on vacuum pump
2. 2
   Sonstigequenched
3. 3
   Extraktionextracted as in Intermediate Example 15(b)
4. 4
   workup.DISTILLATIONThe solvent was distilled off
5. 5
   Sonstigeto afford the product in 54% yield (1.4 g)
6. 6
   SonstigeObserved mass 130.1 [M+H]+ (rt: 0.26 min)

Vorschrift

The solution of ethyl 2-(pyrrolidin-1-yl)acetate (1.8 g, 11.95 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 54% yield (1.4 g). LC-MS (ESI): Calculated mass: 129.1; Observed mass 130.1 [M+H]+ (rt: 0.26 min).

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