Reaktion #9229

Reaktionsgleichung

1-(6-phenylacetylenyl-2-benzothiazolyl)-3-ethylurea

→

desired compound

Ausbeute 41.0%

1-(6-(2(Z)-Phenylvinyl)-2-benzothiazolyl)-3-ethylurea

Ausbeute 41.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas purged with nitrogen gas
2. 2
   Sonstigeby bubbling of hydrogen gas
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated
5. 5
   Sonstigepurified by preparative TLC

Vorschrift

A suspension of 1-(6-phenylacetylenyl-2-benzothiazolyl)-3-ethylurea (0.032 g, 83% purity by weight, 0.083 mmol) and Lindlar catalyst (0.030 g, 5% weight purity, 0.012 mmol, 0.15 eq) in 2 mL ethanol was purged with nitrogen gas, followed by bubbling of hydrogen gas. It was stirred under hydrogen atmosphere for about 36 hours. The mixture was taken up in 10 mL MeOH, filtered, concentrated, and purified by preparative TLC to give 0.011 g (41%) of the desired compound. LC/MS 324 (M+1); LC retention time 2.84 min.

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