Reaktion #9224

Reaktionsgleichung

2-amino-6-bromo-benzothiazole

triethylamine

ethyl isocyanate

→

desired compound

Ausbeute 94.0%

1-(6-Bromo-2-benzothiazolyl)-3-ethylurea

Ausbeute 94.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered off
2. 2
   Waschenwashed with Et2O
3. 3
   Sonstigedried under vacuum

Vorschrift

A suspension of 2-amino-6-bromo-benzothiazole (6.12 g, 26.2 mmol), triethylamine (7.30 mL, 52.4 mmol, 2.0 eq), and ethyl isocyanate (4.15 mL, 52.4 mmol, 2.0 eq) in 50 mL toluene was heated at about 90° C. for about 15 hours. The precipitate was filtered off, washed with Et2O, and dried under vacuum to give the desired compound 7.39 g (94%). LC/MS 300.0 (M−1); LC retention time 3.01 min.

Quelle