Reaktion #9222

Reaktionsgleichung

2-amino-6-benzyl-benzothiazole

triethylamine

ethyl isocyanate

→

desired compound

Ausbeute 56.0%

1-(6-Benzyl-2-benzothiazolyl)-3-ethylurea

Ausbeute 56.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered off
2. 2
   Waschenwashed with Et2O and MeOH
3. 3
   Sonstigedried under vacuum

Vorschrift

A suspension of 2-amino-6-benzyl-benzothiazole (0.040 g, 0.17 mmol), triethylamine (0.104 mL, 0.77 mmol, 4.5 eq), and ethyl isocyanate (0.049 mL, 0.64 mmol, 3.8 eq) in 1 mL toluene was heated at about 95° C. for about 16 hours. The precipitate was filtered off, washed with Et2O and MeOH, and dried under vacuum to give the desired compound 0.029 g (56%). LC/MS 312.3 (M+1); LC retention time 2.62 min.

Quelle