Reaktion #9212

Reaktionsgleichung

1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea

1-(6-Bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea

potassium carbonate

p-fluoro-benzyl-bromide

→

desired compound 13

Ausbeute 19.0%

1-(6-Bromo-7-(4-fluoro-benzyloxy)-2-benzothiazolyl)-3-ethyl-urea

Ausbeute 19.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas reacted

Vorschrift

A mixture of 1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea 6, potassium carbonate and p-fluoro-benzyl-bromide in DMF was reacted to give 0.013 g (19%) of the desired compound 13. 1H NMR (DMSO) δ 1.08 (t, 3H, J=8 Hz CH2CH3), 3.18 (m, 2H, CH2), 5.16 (s, 2H, OCH2Ar), 6.73 (br s, 1H, NH), 7.26 (dd, 2H, J=4, 4 Hz, ArH),7.36 (d, 1H, J=8 Hz, ArH), 7.56 (d, 1H, J=4 Hz, ArH), 7.58 (d, 2H, J=4 Hz, ArH), 10.89 (br s, 1H, NH). HPLC retention time 3.61 minutes.

Quelle