Reaktion #9210

Reaktionsgleichung

1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea

1-(6-Bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea

potassium carbonate

2-bromopropane

→

desired compound 11

Ausbeute 81.0%

1-(6-Bromo-7-isopropoxy-2-benzothiazolyl)-3-ethyl-urea

Ausbeute 81.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas reacted

Vorschrift

A mixture of 1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea 6, potassium carbonate and 2-bromopropane in DMF was reacted to give 0.046 g (81%) of the desired compound 11. 1H NMR (DMSO) δ 10.83 (br s, 1H, NH), 7.55 (d, 1H, J=8.5 Hz, ArH), 7.31 (d, 1H, J=8.6 Hz, ArH), 6.71 (br s, 1H, NH), 4.69 (hept, 1H, J=6.0 Hz, CH), 3.18 (m, 2H, CH2), 1.32 (d, 6H, J=6.1 Hz, CH3), 1.09 (t, 3H, J=7.2 Hz, CH3); LC/MS 358 (MH+); RP-HPLC RT 3.42 minutes.

Quelle