Reaktion #91956

ord-7fe6473a628d4548aa1af40b68f3751d

Reaktionsgleichung

CC(C)(C)C(=O)CBr
1-bromo-3,3-dimethyl-butan-2-one
N=C(N)c1nc(C2CC2)cs1
Compound M
N=C(N)c1nc(C2CC2)cs1
4-cyclopropyl-thiazole-2-carboxamidine
→
CC(C)(C)c1csc(C(=N)N)n1
Compound N
CC(C)(C)c1csc(C(=N)N)n1
4-tert-Butyl-thiazole-2-carboxamidine

Edukte

CC(C)(C)C(=O)CBr
1-bromo-3,3-dimethyl-butan-2-one
N=C(N)c1nc(C2CC2)cs1
Compound M
N=C(N)c1nc(C2CC2)cs1
4-cyclopropyl-thiazole-2-carboxamidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

4-tert-Butyl-thiazole-2-carboxamidine (Compound N) was prepared in analogy to Compound M with procedure shown in Example 10 by using 1-bromo-3,3-dimethyl-butan-2-one instead of 2-bromo-1-cyclopropyl-ethanone. MS: calc'd (MH+) 184, measured (MH+) 184.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09447086B2uspto-grants-2016_09