Reaktion #91883

Reaktionsgleichung

4,6-dichloro-2-(methylthio)pyrimidine

propargylamine

water

→

light yellow solid

Ausbeute 99.4%

6-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine

Ausbeute 99.4%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThen, the formed precipitate was filtered
2. 2
   Waschenwashed several times with cold water
3. 3
   Sonstigedried

Vorschrift

A mixture of 1.00 g (5.13 mmol) of 4,6-dichloro-2-(methylthio)pyrimidine and 0.7 ml (10.3 mmol) of propargylamine in 10 ml of acetonitrile was stirred for 12 hours at 60° C. The reaction solution was poured onto cold water. Then, the formed precipitate was filtered, washed several times with cold water and dried. 1.09 g of a light yellow solid were obtained.

Quelle