Reaktion #91615

Reaktionsgleichung

LiAlH4

(R)-3-hydroxy-3-(5-((2-propylpentyl)oxy)furan-2-yl)propanenitrile

NH3 MeOH CH2Cl2

→

(R)-3-amino-1-(5-((2-propylpentyl)oxy)furan-2-yl)propan-1-ol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigegave
2. 2
   SonstigeYield (0.080 g, 61%)

Vorschrift

LiAlH4 reduction of (R)-3-hydroxy-3-(5-((2-propylpentyl)oxy)furan-2-yl)propanenitrile following the method used in Example 1 gave after flash chromatography purification (2%-20% 7N NH3/MeOH—CH2Cl2 gradient) Example 32 as a colorless oil. Yield (0.080 g, 61%); 1H NMR (400 MHz, CD3OD) δ .6.11 (d, J=2.9 Hz, 1H), 5.11 (d, J=2.9 Hz, 1H), 4.56 (t, J=6.9 Hz, 1H), 3.88 (d, J=5.9 Hz, 2H), 2.65-2.78 (m, 2H), 1.88-1.96 (m, 2H), 1.70-1.80 (m, 1H), 1.30-1.44 (m, 8H), 0.085-0.97 (m, 6H); ESI-MS 270.2 m/z [M+H]+.

Quelle