Reaktion #91580

Reaktionsgleichung

(R)-3-(5-(cyclohexylmethoxy)thiophen-2-yl)-3-hydroxypropanenitrile

→

(R)-3-amino-1-(5-(cyclohexylmethoxy)thiophen-2-yl)propan-1-ol

Lösungsmittel

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigegave
2. 2
   Sonstigeafter purification by flash chromatography (4%-20% 7N NH3/MeOH—CH2Cl2 gradient) Example 5 as a colorless oil
3. 3
   SonstigeYield (0.0185 g, 9%)

Vorschrift

Reduction of (R)-3-(5-(cyclohexylmethoxy)thiophen-2-yl)-3-hydroxypropanenitrile following the method used in Example 1, with the exception that Et2O was used as the solvent, gave after purification by flash chromatography (4%-20% 7N NH3/MeOH—CH2Cl2 gradient) Example 5 as a colorless oil. Yield (0.0185 g, 9%); 1H NMR (400 MHz, CD3OD) δ 6.54-6.59 (m, 1H), 6.00-6.40 (m, 1H), 4.77 (t, J=7.2 Hz, 1H), 3.80 (d, J=5.9 Hz, 2H), 2.86-2.77 (m, 2H), 1.65-1.96 (m, 8H), 1.18-1.36 (m, 3H), 1.00-1.12 (m, 2H); RP-HPLC tR=10.01 min; ESI-MS m/z 252.2 [M−H2O+H]+.

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