Reaktion #91480

Reaktionsgleichung

Benzonitrile

L-cysteine

phosphate

→

2-phenyl-4,5-dihydrothiazole-4-carboxylic acid

2-Phenyl-4,5-dihydrothiazole-4-carboxylic acid

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe precipitate was removed by filtration, and MeOH
2. 2
   Sonstigewas removed
3. 3
   Sonstigeevaporation
4. 4
   workup.ADDITIONTo the remaining solution was added 1M HCl
5. 5
   Sonstigeto adjust to pH=2 under 0° C
6. 6
   FiltrationThe resulting precipitate was filtered

Vorschrift

Benzonitrile (40 mmol) was combined with L-cysteine (45 mmol) in 100 mL of 1:1 MeOH/pH 6.4 phosphate buffer solution. The reaction was stirred at 40° C. for 3 days. The precipitate was removed by filtration, and MeOH was removed using rotary evaporation. To the remaining solution was added 1M HCl to adjust to pH=2 under 0° C. The resulting precipitate was filtered to yield a white solid 2-phenyl-4,5-dihydrothiazole-4-carboxylic acid 42a, which was used directly to next step without purification.

Quelle