Reaktion #91476

ord-0bf7f0028cc841cc8f8dfe7667fb1429

Reaktionsgleichung

COc1cc(C(=O)c2cccc(-c3ccccc3)n2)cc(OC)c1OC
compound 1c
COc1cc(C(=O)c2cccc(-c3ccccc3)n2)cc(OC)c1OC
(6-Phenylpyridin-2-yl)(3,4,5-trimethoxyphenyl)methanone
O=C(O)c1cc(-c2ccccc2)n[nH]1
3-phenyl-1H-pyrazole-5-carboxylic acid
→
COc1cc(C(=O)c2cc(-c3ccccc3)n[nH]2)cc(OC)c1OC
(3-Phenyl-1H-pyrazol-5-yl)(3,4,5-trimethoxyphenyl)methanone

Edukte

COc1cc(C(=O)c2cccc(-c3ccccc3)n2)cc(OC)c1OC
compound 1c
COc1cc(C(=O)c2cccc(-c3ccccc3)n2)cc(OC)c1OC
(6-Phenylpyridin-2-yl)(3,4,5-trimethoxyphenyl)methanone
O=C(O)c1cc(-c2ccccc2)n[nH]1
3-phenyl-1H-pyrazole-5-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

(3-Phenyl-1H-pyrazol-5-yl)(3,4,5-trimethoxyphenyl)methanone (1k) was prepared using the same method as used of compound 1c from 3-phenyl-1H-pyrazole-5-carboxylic acid. 1H NMR (500 MHz, CDCl3 δ 10.97 (br, 1H), 7.77 (s, br, 2H), 7.48-7.38 (m, 5H), 7.14 (s, br, 1H), 3.96 (s, 3H), 3.94 (s, 6H); MS (ESI) m/z 361.1 (M+Na)+, 337.0 (M−H)−.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09447049B2uspto-grants-2016_09