Reaktion #91417

Reaktionsgleichung

N4-cyclopentyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

(3-fluorophenyl)amine hydrochloride

→

titled compound

N4-(3-fluorophenyl)-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe titled compound was synthesized
2. 2
   SonstigeThe crude material was purified by column chromatography
3. 3
   Wascheneluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1)
4. 4
   Waschenthe final product was washed with diethyl ether

Vorschrift

The titled compound was synthesized according to the procedure described for preparation of N4-cyclopentyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine (Example 29) using (3-fluorophenyl)amine hydrochloride instead of cyclopentanamine. The crude material was purified by column chromatography eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1), and then the final product was washed with diethyl ether to afford the titled compound as a white solid. 1H NMR (300 MHz, DMSO-d6) δ ppm 2.04 (s, 3H), 2.20 (s, 3H), 4.51 (d, J=5.6 Hz, 2H), 6.67 (t, J=5.9 Hz, 1H), 7.05-7.29 (m, 4H), 7.60 (bs, 1H), 7.69 (t, J=8.1 Hz, 1H), 8.08 (s, 1H), 8.48 (d, J=4.0 Hz, 1H); MS (ESI) m/z 324.4 (M+1)+.

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