Reaktion #91321

Reaktionsgleichung

4-chlorobenzylamine

methyl 3-bromoisonicotinate

→

title compound

Ausbeute 72.0%

methyl 3-[(4-chlorobenzyl)amino]pyridine-4-carboxylate

Ausbeute 72.0%

Reaktionsbedingungen

Vorschrift

The title compound was prepared in 72% yield from 4-chlorobenzylamine and methyl 3-bromoisonicotinate according to the procedure for Preparation 4A. 1H NMR (400 MHz, CDCl3): δ 8.14 (s, 1H), 7.94 (d, 1H, J=5.0 Hz), 7.82 (br s, 1H), 7.62 (d, 1H, J=5.0 Hz), 7.24-7.32 (m, 4H), 4.47 (d, 2H, J=5.7 Hz), 3.89 (s, 3H). [M+H] calc'd for C14H13ClN2O2, 277, 279. found 277, 279.

Quelle