Reaktion #91172

Reaktionsgleichung

Sulfuric acid

ethyl 4-chloroacetoacetate

2,4-difluororesorcinol

→

title compound

Ausbeute 24.0%

4-chloromethyl-6,8-difluoro-7-hydroxy-2-chromenone

Ausbeute 24.0%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered
2. 2
   Waschenwashed with water
3. 3
   Sonstigedried by nitrogen gas

Vorschrift

Sulfuric acid (2 mL) in a flask was cooled to 0° C. After ethyl 4-chloroacetoacetate (0.62 g, 3.8 mmol) was added thereto, 2,4-difluororesorcinol (0.5 g, 3.4 mmol) was added dropwise thereto. The mixture was stirred at room temperature for 2 hours, and the reactant was placed in ice water. The precipitate was filtered, washed with water, and dried by nitrogen gas to obtain the title compound (0.2 g, 24%).

Quelle