Reaktion #91010

Reaktionsgleichung

methyl 4-(3-chloro-4,5-bis(cyclopentyloxy)benzamido)benzoate

Methyl 4-(3-chloro-4,5-bis(cyclopentyloxy)benzamido)benzoate

→

4-(3-Chloro-4,5-bis(cyclopentyloxy)benzamido)benzoic acid

Ausbeute 77.4%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Vorschrift

4-(3-Chloro-4,5-bis(cyclopentyloxy)benzamido)benzoic acid (AAA-044) (55 mg, 72%) was prepared from methyl 4-(3-chloro-4,5-bis(cyclopentyloxy)benzamido)benzoate (7) (75 mg, 0.16 mmol) using a procedure essentially the same as in Step (ii) for AAA-001, except that 1,4-dioxane (2.5 mL) was used instead of THF: m/z 442 [M−H]− (ES−); 1H NMR (400 MHz, DMSO-d6) δ: 12.74 (1H, br s), 10.45 (1H, s), 7.94 (2H, d), 7.88 (2H, d), 7.69 (1H, d), 7.52 (1H, d), 4.97 (2H, m), 1.99-1.93 (2H, m), 1.73-1.48 (14H, m).

Quelle