Reaktion #90997

Reaktionsgleichung

2-chloro-5-nitro-1,3-bis(trifluoromethyl)benzene

Ethanol

potassium hydroxide

→

2-ethoxy-5-nitro-1,3-bis(trifluoromethyl)benzene

Ausbeute 96.7%

2-Ethoxy-5-nitro-1,3-bis(trifluoromethyl)benzene

Ausbeute 96.7%

Lösungsmittel

DMSO

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was partitioned between EtOAc and water
2. 2
   Extraktionthe aqueous phase was extracted twice with EtOAc
3. 3
   WaschenThe combined organic phases were washed with brine
4. 4
   Trocknendried over MgSO4
5. 5
   Filtrationfiltered
6. 6
   Sonstigethe solvent removed in vacuo

Vorschrift

Ethanol (20 mL, 343 mmol) was treated with potassium hydroxide (956 mg, 17.0 mmol) and the mixture was stirred at RT for 1 h. A solution of 2-chloro-5-nitro-1,3-bis(trifluoromethyl)benzene (1) (1.00 g, 3.41 mmol) in DMSO (10 mL) was added dropwise. The resultant mixture was stirred at RT for 1 h. The mixture was partitioned between EtOAc and water and the aqueous phase was extracted twice with EtOAc. The combined organic phases were washed with brine, dried over MgSO4, filtered and the solvent removed in vacuo to afford 2-ethoxy-5-nitro-1,3-bis(trifluoromethyl)benzene (2) (1.00 g, 93%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) δ: 8.72 (2H, s), 4.21 (2H, q), 1.41 (3H, t).

Quelle